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French prison doctor gave paedophile Viagra before attack

August 30, 2007

PARIS - A French prison doctor yesterday admitted that he had prescribed the sexual performance drug Viagra to a convicted paedophile who went on to abduct and sexually assault a five year old boy.

The extraordinary and disturbing case of Francis Evrard, 61, provoked an emergency meeting of the French government which promised a full investigation and draconian new penalties against paedophiles.

President Nicolas Sarkozy said that he would like to see voluntary “chemical castration” of paedophiles.

Child sex offenders would serve their full terms, with no remission in future, he said.

Those judged dangerous by a panel of doctors would be sent to a new, secure hospital in Lyons.

“Those who refuse to be treated would remain there as long as they are considered dangerous,” the President said.

This implied that offenders who refused chemical castration would stay in the hospital for life.

The prison doctor in Caen in Normandy said that he had no knowledge of the prisoner’s previous record when he prescribed the drug in June - even though Evrard was drawing close to the end of 18 years in jail for raping a child.

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Last week, 45 days after he left jail, Evrard abducted a five years old boy in Roubaix in northern France.

Discount Pharmacy - Buy Pharmacy at discount prices including free shipping.Discount Pharmacy provides confortable and easy way to order discount pharmacy online.He was arrested within hours, thanks to a new public alert system, but had already sexually assaulted the child.

Evrard had the Viagra drugs in his pocket and had taken one before the attack.

He told police that he had been prescribed the drug by his prison doctor but investigators refused to believe him.

His account was confirmed by the public prosecutor’s office in Lille yesterday after the doctor spoke to police on Sunday.

The case has provoked consternation in France and considerable embarrassment for President Nicolas Sarkozy, who has promised to be tough on crime and especially on repeat offenders.

“It is like giving a bomb to a terrorist as he comes out of prison,” said Emmanuel Riglaire, lawyer for the victim’s family.

The President had a 30 minute meeting at the Elysee Palace on Monday with the father and grandfather of the child.

Mustafa Kocacurt, the boy’s father, said Mr Sarkozy had promised him tougher new laws against paedophiles.

“I came here today to ask for a change in the law for monsters like this person,” he said.

“I don’t think it’s normal that he should be outside jail.”

Later President Sarkozy convened an emergency meeting of members of the government, including the prime minister, Francois Fillon, to discuss the Evrard case.

The doctor at the Caen prison, who has not been named, said that Evrard had told him that he wanted to “meet women” as part of his rehabilitation when he left jail.

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AFRICAN EXAMPLES

August 26, 2007

Prof George Albert Omore Magoha, a leading surgeon in this part of the world, is a highly complex man.

You can tell it from the professional organisations he belongs to: the Erectile Dysfunction Advisory Council (Edac), the International Society of Impotence Researc for real men.

Away from administrative duties at the university, Magoha attends to men who struggle with medical complications many prefer not to talk about.

But those complications could make the difference whether a man leaves a generation behind or his kind ends with his death.

Magoha recalls when he was growing up in Yala Gem, Siaya District, it was not uncommon to hear villagers wailing to mourn the sudden death of an old man in the neighbourhood.

When he asked what caused the death, he would be told the old man could not pass urine at the hour of need, however much he tried.

In Magoha’s village, like in any other African society, the idea of a man failing to pass urine was the stuff of myths and taboos, discussed in low tones and only among adults who equally did not know what was going on.

It is life in this world of strange deaths that pushed Magoha into the field of medicine, which few have pursued in Africa.

Highly private man

No wonder Magoha’s clients come from as far as the Democratic Republic of Congo (DRC), Burundi, Tanzania, Uganda and Somalia. Of course Kenyans also visit his Nairobi Hospital clinic.

Magoha describes himself as ” a highly private man”. Students and even some staff at the University of Nairobi agree that Magoha is indeed “a very private person”.

Whether it is the love for privacy that pushed the surgeon into this branch of medicine or it is the profession which pushed him into embracing privacy is hard to tell.

What is clear is that in the line of duty as a medical doctor, Magoha handles highly private and sensitive sicknesses of men.

Magoha is an urologist by. “In very simple terms,” he says, “a urologist is a human plumber.”

He describes it thus: “The plumber deals with human water pipes which transmit urine and seminal fluid, and the organs that feed and supply these pipes.”

In complex terms, Magoha says, a urologist is a fully trained general surgeon with a fellowship diploma or Master of Medicine diploma in general surgery.

But the urologist specialises in urogenital diseases in the kidney, ureter, bladder, prostate, urethra, penis and testes among other parts.

The urologist also manages infertility and erectile dysfunction (erection problems) particularly in men.

As urologist, Magoha has been at the forefront of cutting edge research in cancer of the male genital tract, cancer of the prostate gland, cancer of the penis, testicular cancer, torsion of the testes (twisted testes) and, above all, male erectile dysfunction.

The names sound strange and distant. But in the privacy of clinics and hospital wards, the names stand for real diseases men struggle with daily as they struggle to, as Magoha says, “keep their houses in order”.

Marriages have broken because men have “failed to rise to the occasion” at the critical moment. People have also died because they are unable to pass urine when they are pressed.

Recognized globally

Yet until fairly recently, there was little medical interest in these complications in the East African region. In the villages, marriages broke quietly or after the women exploded with the news that their men could not perform. The explosion would quickly be buried by hushed murmurs and blame passed to the witch in the next home who was bent on ruining people’s families.

When the sexual virility drug Viagra hit the market about eight years ago, few people knew there was a Kenyan brain behind the research and marketing of the wonder innovation.

Magoha was the Kenyan brain behind the drug and he had long researched on the problem of Male Erectile Dysfunction quietly since he graduated from the University of Lagos about 30 years ago.

“I started seeing patients who had a problem they were not very comfortable talking about. I wrote some paper on the problem of Male Erectile Dysfunction and published it in an international journal. Pfizer, the manufacturer of Viagra, picked my name from the Net,” Magoha told The Sunday Standard in an interview this week.

In the inaugural lecture the Vice Chancellor gave recently, he defines erectile dysfunction as “the persistent inability to achieve and maintain an erection sufficient for satisfactory sexual performance”. It is “not the occasional difficulty that may be experienced by men every once in a while”.

In the village where Magoha grew up, there was a plant, locally known as Ogombo, that was popular with men. The men chewed it to deal with their libido problems.

His research have told him that the men in his village were wrong as they confused libido with erectile dysfunction. The libido can rise, but it will not cure erection problem.

Around 2000, the American Biographical Institute recognised Magoha as “most admirable and whose excellent performance in the field of urology will be recognised globally in 1,000 World Leaders of Scientific Influence as a permanent record for research, history and inspiration”.

The specialist in the cancer of the penis, prostate and testes has never turned away a patient at his clinic at the Nairobi Hospital even if the client could not pay.

He has turned down generous job offers at home and overseas because of his commitment to the work he’s doing at the University of Nairobi. “. . . . because I know this is where I’m needed most as a professional training doctors and surgeons for this country and this part of Africa”.

Internet Pharmacy - Buy Pharmacy at reasanoble prices.Internet Pharmacy provides confortable and easy way to order pharmacy via internet.In the 1990s, Pfizer Laboratories, then planning to launch Viagra, approached Magoha for professional advice because he was the East and Central Africa’s representative in Edac for Africa, Middle East, India, Pakistan and Turkey. He still holds this position.

He worked with the Pfizer team on how to approach the cultural barriers that stood on Viagra’s way. He also advised fellow doctors on some of the side effects of the drug before it was launched in Nairobi in October 1998, and in Kampala two months later.

It is Magoha who later lunched the drug in other countries in the region. In 2003, he was in Accra, Ghana, to launch another virility drug, Cialis.

Viagra, Magoha says, came with a number of medical and cultural complications. How was it to be sold in Africa where people do not talk openly about sex and where the erection problem is regarded as a curse and not a disease?

Traditionally, Magoha says, inability of men to “rise to the occasion” has been called impotence. But that is not the case. Men with erectile dysfunction retain other functions like sexual desire and the ability to achieve orgasm or ejection. It affects up to 152 million men worldwide and is tied to age.

About 39 per cent of men aged 40 years and above experience the problem. The numbers of sufferers rise to about 70 per cent among those aged 70 years and above.

The dysfunction can be mild, moderate or complete, Magoha says.

At 70 years, complete dysfunction is recorded in 15 per cent of men, moderate occurs in 34 per cent while mild affects in 21 per cent.

This according to Magoha, makes erectile dysfunction one of the most common diseases among men.

Yet the stigma around this condition makes it hard for men to see doctors over it.

“Most patients do not consult qualified doctors and other health workers. They prefer to consult the traditional medical practitioners and healers because of the stigma and socio-cultural barriers, myths and taboos associated with erectile dysfunction,” says Magoha.

It was around 1990 that the professor came to know that erectile dysfunction was a silent problem among men.

Often, a patient he had examined for other problems would, on reaching the door, turn and say, “anyway doctor I have another very small problem”.

“The ‘very small problem’ would eventually turn out to be persistent inability to achieve and maintain erection sufficient for satisfactory sexual performance,” Magoha says.

The lack of confidence by the patients resulted from the stigma, myths and the feeling of guilt and embarrassment.

It did not help that the most efficient cure — injection of the penis with alprostadil — remained very unpopular with African men in this locality.

“The main reason for this was fear of needles and self-injection, pain and the lack of privacy from the partner who invariably had to know that the sexual process had to be preceded by a penile injection,” Magoha explains.

“In African tradition, this demoralises the men as it tends to imply that they are not men enough,” he adds.

In those days, men treated this problem as an affair between them and the doctor at the worst. They kept their wives away. However, this has changed in recent years.

“Now some come with their wives. The surprise has been that some show up with bottles of wine as a form of appreciation. That is very rare with Kenyans,” Magoha says.

“Usually, it is the wife who delivers the wine in appreciation,” he adds.

Administration and teaching have confined Magoha to seeing just about five patients every week. Most of the patients, some of whom travel from far, say they picked his name from the Internet.

A tablet of the new virility drugs like Viagra costs $10 (Sh600) and usually, the drug comes in a mandatory package of two tablets for a start.

“Those who can afford come and pay for it. Unfortunately, the disease, just like the other diseases afflicts both the poor and the rich. Sometimes these drug companies give us free samples. I give these to desperate cases who cannot afford,” Magoha says.

“In dealing with erectile dysfunction, we are just reorganising your own systems in the body. There is a chemical in the body we rejuvenate so that it does not die too early,” he explains.

A tablet of Cialis, Magoha says, can stay in the system for up to three days.

“Since we are not animals, sex is not something you go for everyday. It is, therefore, not a question of how many tablets you require. All the same, a packet of two will cost you Sh1,400. It is a reasonable price to pay for keeping your home intact,” Magoha says.

The VC has also researched and published extensively in diseases affecting the male genital tract including the prostate and testes. He has researched on cancer of the penis and dismisses as “rubbish” the belief that people who are circumcised do not contract the disease.

“Those who survive are those circumcised at very early age, at around one month. But if you observe basic hygiene and stay clean, there is no reason for you to contract cancer of the penis,” he says.

Magoha got invitations to meetings during the trials on Viagra. The first meeting was in Cape Town, followed by others in Dubai and Cairo.

His role was to advise fellow doctors on safe use and cultural limitations that faced Viagra in Africa, the Middle East and Asia.

The professor confesses that Viagra “sells very well” in Kenya, despite the fact that it costs over Sh600 per tablet.

“If you want to put your house in order you just work out how to accommodate the price in your budget even if only for one evening in a month,” he says.

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STUDY FINDS VIAGRA INCREASES RELEASE OF KEY REPRODUCTIVE HORMONE

August 23, 2007

The little blue pill may do more than get the blood pumping.  Sildenafil - the generic name for Viagra - also increases release of a reproductive hormone in rats, according to a new study.

Researchers at the University of Wisconsin-Madison report this month that sildenafil increases the amount of oxytocin released by stimulation of the posterior pituitary gland, a small structure directly underneath the brain that regulates hormone levels in response to neural signals.

The finding is the first indication of a chemical mechanism through which erectile dysfunction drugs like Viagra may have physical effects besides increasing blood flow to sexual organs, says study author Meyer Jackson, a physiology professor at the UW-Madison School of Medicine and Public Health.

Sometimes called the “love hormone” or “cuddle chemical,” oxytocin plays several important roles in social interactions and reproduction, including triggering uterine contractions and lactation.  It is also released during orgasm and has been linked to sexual arousal.

Oxytocin release is regulated by an enzyme that acts like a braking system, limiting hormone release by dampening neural excitation of the cells.  This same enzyme, phosphodiesterase type 5, also limits blood flow by contracting the muscles around blood vessels.

In both places, sildenafil works by blocking this enzyme, essentially releasing the brakes, explains Jackson.  In blood vessels, relaxing smooth muscle increases blood flow, which corrects erectile dysfunction, and in the posterior pituitary, the cells become more responsive.  ”The same stimulation will produce more [oxytocin] release.”

He says, “I think this is a missing link in terms of trying to sort out the issues around whether there are additional effects of phosphodiesterase type 5 inhibitors,” which include Viagra, Levitra and Cialis.

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The new report was published online Aug. 9 and appears in an upcoming issue of the Journal of Physiology.

In the study, the scientists measured oxytocin released from rat pituitaries in response to neural stimulation.  When the pituitaries were treated with sildenafil, they responded to the stimulation by releasing three times as much oxytocin as they did without the drug.

Importantly, the drug had little if any effect on hormone release in the absence of stimulation, Jackson says.

“Erectile dysfunction drugs do not induce erections spontaneously, they enhance the response to sexual stimulation,” he says.  ”The same thing is happening in the posterior pituitary - Viagra will not induce the release of oxytocin on its own, but it will enhance the amount of release you get in response to electrical stimulation.”

Though he doesn’t think his findings raise any significant safety issues related to Viagra use, he does think it provides strong rationale for studies of additional effects and new potential uses.

“A big question raised by our study is, will sildenafil do the same thing to the nerve terminals that release oxytocin [in the brain]?” he says.  The cells that supply oxytocin to the pituitary come from a brain structure called the hypothalamus, which also sends hormones throughout the brain.

Though sildenafil’s effects on these pathways are still unknown, work by other researchers has shown that oxytocin-sensitive cells in the brain play a role in the neural control of erectile responses, suggesting that Viagra and its kin may work through multiple channels.

The famous blue pills could have other uses as well.  Oxytocin has been linked to the ability to make strong social bonds, while sildenafil was recently shown to improve hamsters’ abilities to adjust the timing of their internal clocks to overcome simulated jet lag.

“This is one piece in a puzzle in which many pieces are still not available,” Jackson says.  ”But it raises the possibility that erectile dysfunction drugs could be doing more than just affecting erectile dysfunction.”

The study was co-authored by Zhenjie Zhang and Vitaly Klyachko.  Funding for the research came from the National Institutes of Health.

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Paedophile re-offends with Viagra

August 19, 2007

Judicial authorities did not immediately respond to his claim that a doctor had prescribed the virility-enhancing drug. The 61-year-old paedophile was arrested on Wednesday in the northern French town of Roubaix, near Lille, after abducting the boy. President Nicolas Sarkozy is due to discuss new measures against repeat offenders with ministers on Monday. - Sapa-DPAParis - The French are outraged over a multiple paedophile who re-offended shortly after being released from prison with the virility-enhancing drug Viagra in his pocket, the Paris-based Journal du Dimanche reported on Sunday.

According to the paper, the 61-year-old man said he was given the drug by a prison doctor.

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His statement has so far not been confirmed by officials.

“They give him the weapons to start again,” lawyer Emmanuel Rigilaire told the paper.

Rigilaire represents the family of five-year-old Enis, who was abducted and abused by the paedophile last week.

The homosexual paedophile has served three lengthy prison sentences since 1975.

Experts had considered him as dangerous and thought it was unlikely that he could be reintegrated into society, according to the paper.

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Drug makers triple spending on marketing as regulation softens

August 18, 2007

SAN FRANCISCO: Drug makers tripled their spending on U.S. marketing in the past decade to $30 billion a year as government action against misleading advertisements declined, a study has found.

The spending was driven by print and TV ads to consumers, free samples and promotions to physicians, according to a study in the New England Journal of Medicine released Thursday. U.S. regulators sent 21 warning letters to drug makers in 2006 for misrepresenting the risks and benefits of their products, down from 142 letters nine years earlier, the researchers said.

The findings suggest drug companies have been undaunted by criticism since 2004, when Merck’s widely promoted Vioxx pain reliever was withdrawn from the market after safety risks came to light. Last month, a “Viva Viagra” ad campaign from Pfizer, set to an Elvis tune, was criticized by AIDS activists for promoting the impotence pill as a “party drug.”

“It’s important that these ads be regulated, and the regulations be enforced,” said Julie Donohue, a health policy researcher at the University of Pittsburgh School of Public Health, and the study’s lead author, in a telephone interview. “It’s the FDA’s responsibility to make sure the information in the ads is good.”

The study was sponsored by the U.S. National Institutes of Health and the Alfred P. Sloan Foundation.

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Many of the top-advertised products are for chronic conditions. London-based AstraZeneca’s Nexium for heartburn was the most promoted drug in 2005, supported by $224 million in advertising, according to the study. It was followed by the sleep aid Lunesta, marketed by Sepracor, based in Marlborough, Massachusetts. Vytorin, a cholesterol-lowering drug, ranked third in ad spending, the researchers said.

The Pharmaceutical Research and Manufacturers of America, an industry trade group in Washington, said in a statement that direct-to-consumer advertising “improves patient understanding of disease and available treatments.”

“The New England Journal study underplays the valuable role that DTC has in educating and empowering patients to take initiative in their own health care,” said Diane Bieri, general counsel for the pharmaceutical group.

Discount Pharmacy - Buy Pharmacy at discount prices including free shipping.Discount Pharmacy provides confortable and easy way to order discount pharmacy online.Researchers found that the advertising typically begins early in the life of a product. Of the top 20 advertised drugs, 17 had ad campaigns from their first year on the market.

A report last year from the Institute of Medicine proposed a moratorium on direct-to-consumer TV ads during a product’s first two years following approval, when more data on the drug’s long-term safety can be gathered. The institute, established in 1970, advises the government on health issues.

Proposals to give the FDA authority to ban advertising for a new drug did not win inclusion in drug-safety measures that have been passed by the House and Senate. A final version of the legislation awaits negotiations when Congress returns to session in September.

The drug industry group proposed self-regulation in 2005, asking its members to withhold ads for new drugs long enough to educate doctors about benefits and risks. The guidelines did not specify how long companies should wait.

Drug makers support some government oversight of advertising, including a proposal to allow the FDA to hire 27 more employees to review TV commercials for accuracy before they go on the air, Bieri said.

The FDA had three employees reviewing such ads in 2002 and four in 2004, according to the study. During that period, spending on direct-to-consumer ads shot up 45 percent to $4.2 billion, from $2.9 billion, researchers said.

Most of the total spending on marketing is for product samples and other promotions the drug makers provide to doctors for what they call educational purposes.

Advertising appears effective for drug makers, previous research has shown.

“What comes out of the research that we’ve done is the importance of advertising and how that’s impacting the way that consumers are viewing medication and self-medication in particular,” said Glen Murphy, managing director of AC Nielsen in China.

For every 10 percent increase in advertising for a given medicine, prescription sales of drugs across the same class rise 1 percent, according to a 2003 study by the Henry J. Kaiser Family Foundation, based in Menlo Park, California. In 2002, every extra dollar drug companies spent on ads pushed up revenue by $4.20, the Kaiser research found.

“Direct-to-consumer advertising increases sales of drugs, and studies have shown a lot of it is misleading,” said Lisa Bero, a pharmacologist who has researched drug marketing at the University of California, San Francisco. “I think it means we’ll be getting more and more misleading information.”‘

GlaxoSmithKline, the world’s second-largest largest drug maker, spent the most on direct-to-consumer advertising in 2006, $848 million, according to Nielsen Monitor-Plus data. Pfizer, the biggest drug maker, was second, spending $641 million.

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YOU, ME AND VIAGRA

August 10, 2007

It has made untold billions for one drug company but, a decade after its unveiling, the gloss is fast fading from the wonder pill, says Lois Rogers.

It was billed as the great marriage saver of the late 20th century. Viagra was the drug that would fix all but the most broken-down relationships, sending all those involved on to a lust soaked cloud of successful sexual chemistry. But no one in those heady days could quite imagine the side-effects - emotional as well as physical.

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Since Viagra launched it has become, in common with similar drugs, a pill …

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Plugging drugs on television

August 7, 2007

When he feels his life is spinning out of control, TV mobster Tony Soprano reaches for Prozac, an antidepressant developed by Eli Lilly and Co.The names of popular drugs Viagra and Botox frequently come up in TV shows.


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There were 462 mentions of prescription drugs on TV last year, more than double the number from just two years earlier. But while consumer-product giants such as Coca-Cola, Toyota and BlackBerry shell out hundreds of millions of dollars to TV and movie studios to mention their products in story lines, it’s a mixed blessing for drug companies to have such exposure.

Discount Pharmacy - Buy Pharmacy at discount prices including free shipping.Discount Pharmacy provides confortable and easy way to order discount pharmacy online.”I don’t think the drug industry really likes this trend at all,” said Rob Frankel, a branding expert in Los Angeles. “Some of the jokes about Viagra and Botox are pretty sarcastic or disparaging. They get darker and deeper when they start mentioning Prozac and (anxiety medication) Xanax.”

In an episode of “Freestyle” on HGTV, a homeowner defined a comforting room in her house as her “Prozac room.” In an episode of “House,” a sign over the coffee machine in the doctors’ conference room says “Good coffee - cheaper than Prozac!”

Drug companies are relatively small players in product placement, with none breaking into the top 10. Bigger companies such as Nike and Hewlett-Packard dominate, according to Nielsen Product Placement.

Overall, companies paid $3.36 billion globally last year to place their products in TV, film and other media, up 37 percent from a year earlier, according to PQ Media.

Some pharmaceutical companies have acknowledged paying for TV plugs. Lilly says it doesn’t pay.

The FDA does not have an explicit position on product placement. In normal advertising, drug makers are prohibited from advertising the benefits of their drugs without mentioning possible risks.

Despite the billions of dollars the pharmaceutical industry spends on direct-to-consumer advertising, drugs still don’t have the instant connection with consumers that everyday products such as soft drinks and sports cars have, some media experts say. Therefore, television shows can do only so much to plug a drug.

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Nationwide spending on impotence drug Viagra is at its lowest in West Berkshire

August 2, 2007

IT SEEMS southerners aren’t so soft after all.
Figures obtained by a Sunday newspaper show that people in West Berkshire spend the least amount of money on Viagra compared to other areas in England.

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On average, people in this area only spend 70p per year on the impotence-correcting drug.
This is less than half the amount spent by people in Knowsley, near Liverpool, who fork out £1.80.

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